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Since nitric oxide is a well-established vasodilator, the theoretical chain runs: more precursor amino acids more NO production vessel dilation blood pressure support

In total, we generated six LMNA transgenic zebrafish lines: LMNA (WT), 3 novel and 2 known pathogenic mutant lines, including LMNA (L35P), LMNA (E358K), LMNA (R453W), LMNA (W520G), and LMNA (A539V), and which were validated by fin-clip, and the presence of the intended mutations was confirmed by comparing them to the LMNA (WT) sequence (Fig

However, the addition of these chemotherapeutics does not yield improved clinical outcomes, presumably because simtuzumab exclusively inhibits extracellular LOXL2

Integrated transcriptomic and metabolomic analyses indicated that the key differential genes and metabolites were predominantly concentrated in starch and sucrose metabolism and arginine and proline metabolism (Fig